Sclerostin是敌还是友：在关节炎中的作用？

Sclerostin(SOST)是主要来源于骨细胞(Osteocytes)的蛋白质,可显著抑制骨形成(boneformation)。...

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Wehmeyer C, Frank S, Beckmann D, et al. Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction[J]. Science translational medicine, 2016, 8(330): 330ra35-330ra35.

El-Bakry S, Saber N, Zidan H, et al. Sclerostin as an innovative insight towards understanding Rheumatoid Arthritis[J]. The Egyptian Rheumatologist, 2016, 38(2): 71-75.

Sims N A. Bone: Does anti-sclerostin therapy promote inflammation in rheumatoid arthritis?[J]. Nature Reviews Endocrinology, 2016, 12(6): 314-316.

Sclerostin (SOST) 是主要来源于骨细胞(Osteocytes)的蛋白质, 可显著抑制骨形成(bone formation)。研究表明，RA病人血清中SOST的中位水平达2000ng/dl (800–3300 ng/dl), 显著高于对照者的210 ng/dl (150–2859) (Z = −4.47, p 

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